Oct 21, 2025

By unifying real-time and retrospective data across siloed systems, CalmWave empowers hospitals with the clarity to drive safer, smarter care CB Insights today named CalmWave , creator of the Calm ICU™ and leader in eliminating non-actionable alarms through healthcare data science and Transparent AI, to its seventh annual Digital Health 50 showcasing the 50 most promising private digital health companies in the world. “The 2025 Digital Health 50 winners are high-momentum companies poised to define the next era of healthcare,” said Ellen Knapp, Principal Analyst at CB Insights. “This year's cohort is advancing the shift from reactive to proactive care, developing AI solutions tailored to healthcare's unique regulatory environment, and addressing critical sector-wide challenges from care access to provider burnout and workforce shortages.” “At CalmWave, we're proving that data, when harnessed transparently and responsibly, can restore focus to the bedside and improve care for everyone in the room,” said Ophir Ronen, CEO, CalmWave. “This recognition reaffirms our mission to empower the people behind the monitors – nurses, clinicians, and patients – by transforming the way healthcare systems operate.” The list primarily includes early- and mid-stage startups driving innovation across digital health. Our research team picked winning companies based on CB Insights datasets, including deal activity, industry partnerships, team strength, investor strength, employee headcount, and proprietary Commercial Maturity and Mosaic scores . We also dug into Analyst Briefings submitted directly to us by startups. The Calm ICU™ is a signal-led critical care environment, powered by CalmWave, where non-actionable noise is cut and clinical urgency breaks through. The system uses Transparent AI, which makes the reasoning and data behind its conclusions both visible and fully understandable to users, to help healthcare organizations optimize operations and confirm they are making well-informed, data-driven decisions. By breaking down long-standing silos, CalmWave equips hospitals with previously inaccessible insights, helping entire health systems see clearly and act with confidence. Quick facts on the 2025 Digital Health 50: The 50 winners span categories such as care delivery, revenue cycle management, drug discovery & development, and diagnostics. This year's cohort is deploying AI across a wide variety of use cases, with notable adoption of agentic AI, voice AI, and automated provider workflows. Collectively raised $2B in equity funding in 2025 YTD (as of 10/14/2025). 52% are early-stage companies (seed/angel or Series A funding). Established 140+ business relationships since 2024 with industry leaders including Cleveland Clinic IBM , and Novartis About CB Insights CB Insights is the leader in predictive intelligence on private companies. It delivers instant insights that help you source and analyze private companies, focus on the right markets, and stay ahead of competitors. Our AI agents are powerful because they translate signals into the exact outputs your teams need to move first — defensible, sourced, and board-ready. To learn more, please visit www.cbinsights.com About CalmWave CalmWave's mission is to objectively improve healthcare, starting with safely eliminating non-actionable alarms. Alarms triggered by bedside monitoring systems that do not require immediate intervention or clinical response comprise 80-99% of all audible alarms in intensive care units (ICUs). They contribute to a well-recognized and widespread issue known as alarm fatigue, endemic to every hospital worldwide. Alarm fatigue, rampant in the modern healthcare system, causes great stress for clinicians and patients, ultimately impacting patient outcomes and staff retention. Using Transparent AI, CalmWave outlines the rationale behind each optimized setting, empowering a hospital's clinical staff to evaluate and implement optimized alarm limit recommendations in the bedside monitor at the patient's bedside using the CalmWave Operations Platform, which integrates seamlessly with the hospital's EMR and medical device middleware systems. Doing so remediates alarm fatigue and can improve staff retention and patient outcomes. Visit CalmWave.ai for more information and follow us on LinkedIn and X View source version on businesswire.com: https://www.businesswire.com/news/home/20251021946063/en/ Contacts CB Insights media@cbinsights.com CalmWave press@calmwave.ai